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Clomipramine

Clomipramine is a psychotropic agent used to treat obsessive-compulsive disorder (OCD). Clomipramine shares structural similarities with a class of antidepressants known as tricyclic antidepressants (TCAs). The exact mechanism by which Clomipramine exerts its therapeutic benefits is not fully understood. However, similar to other TCAs, Clomipramine is thought to enhance the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain that nerves use to communicate with one another) by blocking their reuptake and prolonging their activity. Clomipramine also has anticholinergic properties which means it blocks the action of another neurotransmitter, acetylcholine. This increases the risk for certain side effects. It also has weak antihistamine properties which appear to play a role in the mild sedative effects observed with use. Clomipramine was approved by the US FDA for the treatment of OCD in 1991.

Other names for this medication:
Clomipramine, Anafranil, Clofranil, Clomipramina, Clora, Zenil,

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Homologous proteins have been recently detected in other, non-photosensitive, cells of vertebrates, where they are thought to be associated with other systems of signal transduction. Our global sample of enzymatically normal B alleles and A, A-, and Med alleles with reduced enzyme activities reveals many previously uncharacterized silent-site polymorphisms. A titanium membrane was adapted and fixed, covering the sockets, which remained for at least 10 weeks. Generalized scleroderma or progressive systematic sclerosis (Goetz) or scleromesoderma Increasing the dose of any of the inhibitors reduced the numbers of apoptotic figures below those of control cultures, indicating that the inhibitory response is dose dependent.

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Post-operative condition of breast cancer patients from standpoint of psycho-oncology--preliminary results. We describe a new pararectus retroperitoneal approach to the kidney, which allows easy identification and occlusion of the renal vessels before mobilization of the kidney. Beverage and water intake of healthy adults in some European countries. Does mental training improve learning to walk with an above-knee prosthesis?

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4,5-Diaminofluorescein (DAF-2) is widely used for detection and imaging of NO based on its sensitivity, noncytotoxicity, and specificity. Colloid concentration measurements were carried out using an in-situ liquid particle counting system. These results exclude a common mechanism for M/L-cone maturation: they either transdifferentiate from S-cones or develop independently. Jejunal pouch reconstruction after total gastrectomy for cancer.

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HCECs produce antimicrobial peptides, LL-37, hBD2 and hBD3, in response to stimulation of HKCA, which suggests a novel innate immune mechanism of the ocular surface in defense against fungal invasion. Differences in HER2 over-expression between proximal and distal gastric cancers in the Chinese population. Selective membrane fusion underlies subcellular compartmentation, cell growth, neurotransmission and hormone secretion. Plasma, red cell, and total blood volume changes following cardiac surgery.

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Knowledge of the factors involved may lead to new approaches in the management of rectal cancer. A field-based microcosm approach was tested to identify deterioration of sediment quality in waterways using freshwater macroinvertebrates. To investigate the effects of selective beta(2)- and selective beta(3)-adrenoceptor (AR) agonists on prostaglandin (PG) E(2)-induced bladder hyperactivity in conscious free-moving rats. The use of new techniques, including nucleic acid hybridization and direct fetal or trophoblastic cell sampling, continues to accelerate our knowledge of the epidemiology, microbiology, and immunology, as well as means to diagnose, treat, and prevent individual congenitally transmitted infections. A SIMPLE DEFINITION OF ANALYTIC FUNCTIONS AND GENERAL MULTIFUNCTIONS.

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In vitro modulation of microRNA-125a expression in 3T3-L1 adipocytes did not affect glucose uptake. The MilkBovExp chip representing 90 genes encoding transcription factors expressed in the bovine mammary gland and/or involved in mammary gland signaling pathways was designed for further investigation of impact of gene expression and/or its encoded products on milk traits performance.

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The aim of this study was to analyze the effects of an ethanolic extract of Piper betle leaves on the generation of reactive oxygen species in erythrocytes sourced from vitiligo patients. The initiation of tissue-specific basal transcription is accompanied by the induction of two DNase I hypersensitive sites, and this chromatin remodeling event requires binding of the key osteogenic factor RUNX2/CBFA1 to the OC promoter. The problem of low female literacy rates in Africa starts with low primary school enrollment, particularly in areas of high food insecurity. Persistence of elevated serum creatinine levels and accompanying hematuria led us to perform a renal biopsy, and MPA was diagnosed on the basis of light and immunofluorescence microscopy. Radiological study of the small intestine in different affections

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Effects of TJ-9 Sho-saiko-to (kampo medicine) on interferon gamma and antibody production specific for hepatitis B virus antigen in patients with type B chronic hepatitis. 84 sessions were conducted during a randomised controlled trial to test the effectiveness of a population-based smoking intervention in women during the postpartum period.

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Branched 1,6-1,3-beta-glucans from Phytophthora sojae cell walls represent pathogen-associated molecular patterns (PAMPs) that have been shown to mediate the activation of plant defence reactions in many legumes. Amino Acid PET - An Imaging Option to Identify Treatment Response, Posttherapeutic Effects, and Tumor Recurrence?

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The total concentration of mercury was determined in samples of water, soil and sludge from the Mediterranean coastal area of Southeast Spain (Motril), where Hg contamination is produced primarily by a local paper mill. Limited Stage Aggressive Non-Hodgkin Lymphoma: What Is Optimal Therapy?

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Long-term treatment with lamivudine is required to control viral replication in patients with hepatitis B e antigen-negative clarithromycin dosage for bronchitis chronic hepatitis B, but is associated with a high rate of viral resistance. Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop. Nucleotide sequence of a Clarkia breweri cDNA clone of Ipi1, a gene encoding isopentenyl pyrophosphate isomerase.