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Protein tyrosine kinases such as HER-2/c-erbB-2 and the epidermal growth factor receptor (EGFR) have been linked specifically to breast cancer, and perturbations of HER-2 affect response to chemotherapy. Limited use of the Cre/loxP recombination system in efficient production of loxP-containing minicircles in vivo. This study compared the efficacy of immobilization using the collar to that of a short spine board. The overall clinical performance of the citrate-based solution used without manual rubbing was similar to that of the solution containing HPMC.

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Among nonprofit hospitals, small size (substantially fewer than 150 medical-surgical beds), or large size and having an inpatient PC program with more than three PC staff per 100 GMS beds, or an interdisciplinary PC-certified team, is associated with significantly lower EoL hospital utilization and percentage of deaths occurring in the inpatient setting. Three dimensional structure of the endochorion in wild type Drosophila melanogaster.

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Despite final results were negative, low birth weight could be a good parameter of environmental contamination and should be closely monitored in the studied area. The probable nature of the cytochalasin B binding site within the oral apparatus is discussed. Fatigue is one of the most limiting symptoms in multiple sclerosis (MS) and the mechanisms underlying its origin are poorly understood. Anticoagulation management strategies for patients on warfarin who need surgery. The preventive measures of ventilator-associated pneumonia related to the endotracheal tube include these two mechanisms.

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Allergic and asthmatic individuals may have exercise-induced respiratory problems and sports may induce, in some cases, allergic problems. These results suggested that antisense gene of HBV can be successfully transferred and transcripted in target cells through retroviral vector mediated gene transfer and the antisense retroviral vectors may be potentially useful for anti-HBV gene therapy. Unilateral efferent duct ligature mainatined for 24 h in adult Wistar rats, shows that the secretion of testicular fluid elevates progressively with the age of animals (from 10 mg/g/h at a 100 days to 13 mg/g/h at a 150 days). A modified back-to-back colonoscopy using AFI and WL was conducted for 167 patients in the right-sided colon including cecum, ascending and transverse colon by a single experienced colonoscopist.

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Risk of contact allergy and dermatitis at a wind turbine plant using epoxy resin-based plastics. Membranous glomerulonephritis associated with splenic marginal zone lymphoma mimicking multiple myeloma.

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We also determined asymmetric-IgG production in IL-6-deficient pregnant mice. Chairs of audit groups and audit support staff in hospital, community and primary health care and audit leads in health authorities in the North West Region.

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The similarities of light chain deposition disease and AL amyloidosis are discussed. Auto-antibodies in prostate cancer: humoral immune response to antigenic determinants coded by the differentially expressed transcripts FLJ23438 and VAMP3.

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The effect on sitting posture of a desk with a 10 degree inclination for reading and writing. Personal semantic memory: insights from neuropsychological research on amnesia. In the cadaver specimens, the mean distance between the neurovascular bundle and the medial border of the extensor hallucis longus (EHL) was 9.0 (range, 8 to 10) mm.

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In this context, beta-blockers are usually recommended for these patients, since, reducing heart rate and blood pressure, favorably influence clinical symptoms. These results strongly suggest that while BubR1 is required to promote stable microtubule kinetochore attachment, CENP-E appears to be required to destabilize kinetochore attachment. The photon counting histogram (PCH) analysis of the fluorescence fluctuations provides the molecular brightness (epsilon) and the average number of fluorophores (N) in an open observation volume. The chemoresistance level was established from the viability index (IC50) in the presence of doxorubicin. Characterization of vanilloid receptors in the dorsal horn of pig spinal cord.

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Between October 1999 and October 2004, 216 patients with low risk prostate carcinoma were treated with (125)I (200 patients) or (103)Pd (16 patients) permanent seed implantation. With a median follow-up of 15 months (range, 3-25 months), 5 patients remain in remission.

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Ranitidine increases oral absorption of triazolam in both young and older people. Loss of OsRAD1 led to abnormal chromosome association and fragmentation upon completion of homologous pairing and synapsis.

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Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines. The V617 is conserved in two other mammalian JAKs, JAK1 and Tyk2. Although all cancers do not appear to sustain themselves with cancer stem cells, but also through a dominant cell population, creating strategies for cancer treatment which include cancer stem cells as targets seems reasonable. The results suggest the existence of glycine sensors in the hepato-portal system that exert reflex regulation on the pancreatic vagus nerve activity.

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However, this reduction is only comparable with a limited degree of protective vaccination coverage. These results establish Foxd3 as a factor required for the maintenance of progenitor cells in the mammalian embryo.

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Posttraumatic stress disorder comorbid with major depression: factors mediating the association with suicidal behavior. Rather, UV radiation selectively activated lymph node B cells, with these cells being larger and expressing higher levels of both anti-major histocompatibility complex II and B220 but not co-stimulatory molecules. Effect of photic manipulation on the level of melatonin in the retinas of frogs (Rana tigrina regulosa).

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These data support the findings from population based studies in esophageal cancer and other gastrointestinal tumors, suggesting that a higher nodal count favorably influences survival. In contrast, no effect on the expression of c-myc, fra-1, v-jun or actin mRNA was detected at this time. The results show that the cobalt accumulated maximally in kidney followed by liver, intestine, blood, spleen, and lung in decreasing order, in a dose-dependent manner. We extracted data in duplicate on the type of participants, the dose and duration of treatment, the outcome measures, the randomization procedure, concealment of allocation, and completeness of follow up. Work in several laboratories has recently uncovered a novel yeast gene, ELG1, which seems to play a central role in keeping the genome stable.

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Comparison of a treatment strategy combining CCI-779 plus DTIC versus DTIC monotreatment in human melanoma in SCID mice. The two approaches provided the means of accurately comparing DNA repair kinetics at individual level, taking also into account the experimental variability which poses serious doubts on the suitability of the comet assay. The results of this study indicate that at control vascular tone the catecholamines norepinephrine and epinephrine increase pulmonary vascular resistance and decrease pulmonary vascular compliance through alpha 1- and alpha 2-receptor-mediated stimulation with precapillary alpha 1- and alpha 2-receptors and postcapillary alpha 2-receptors interacting with precapillary and postcapillary beta 2-receptors. To determine the nature of impaired hematopoiesis, we carried out cell culture studies of mutant embryonic stem (ES) cells and cells from the aorta-gonad-mesonephros (AGM) region of E10.0 mutant embryos. Frontline treatment of advanced gastric cancer with docetaxel and granulocyte colony-stimulating factor (G-CSF): a phase II trial.

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In one of them, the levels of the tumor markers decreased from the initiation of the injection of M-CSF, but gradually increased to the initial levels after the last injection. Five human bladder carcinoma cell lines, representing a variety of differentiation states, were grown in cell culture.

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v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter. Increasing iodine concentrations in milk via intramuscular injection of iodine could provide a method for significantly increasing iodine intakes of humans, in particular, children. Molecular profiling of Lactobacillus, Streptococcus, and Bifidobacterium species in feces of active racehorses. Lymphomas of mucosal-associated lymphoid tissue in common variable immunodeficiency. Despite early diagnosis and valve ablation, progressive renal impairment develops in a significant proportion of boys born with posterior urethral valves.

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We describe the extent to which endogenous and exogenous factors regulate Mphi uptake of SPIO particles. As a first approach to delineate these effects, the present work was conducted to assess the effects of high-LET radiations on murine spleen cells ex vivo and in vitro. Moreover, even if the difference in reproducibility between the two systems of sampling is statistically significant, in samples that resulted positive at repetition high-grade lesions were not found at the time of HPV screening test.

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The use of glycopeptides in properly selected patients at high risk of methicillin-resistant S. Metastatic neoplasms in the larynx from remote primary tumors are uncommon, and laryngeal metastasis originating from the colorectum is extremely rare. Lower literacy and minority status are important determinants of understanding consent information. Photographic documentation of clinical cases enhances the medical record, communication with colleagues, and client education. Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of Bisphenol A.

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Evidence from recent randomized controlled trials led to changes in the national guidelines for administration of oral antiplatelet therapy in patients with acute coronary syndromes. To date, each manufacturer has provided its own reference range resulting in lack of uniformity. Spin-polarized scanning tunnelling microscopy reveals that adjacent spins are not perfectly antiferromagnetic but slightly canted, resulting in a spin spiral structure with a period of about 12 nm. Genetic alterations of each are associated with abnormal platelet development, as well as predisposition to leukemia. The clinical expression is highly variable, with many atypical manifestations.

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(3) Peritonitis remains the main cause of morbidity in PD patients. The enzymes analyzed were ATPase, which belongs to the transport mechanism in lens epithelium cells, hexokinase, the key enzyme of the glycolysis pathway, G6PD, which provides NADPH to the glutathione system and catalase, which protects the cells from H(2)O(2). The objective of these studies was to investigate the applicability of an online direct inject HPLC method for the preformulation screening of pharmaceutical agents in pressurized metered dose inhalers (MDIs).

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Negligence and embryo protection: a new frontier for medical law? Interaction between Cryptosporidium oocysts and water treatment coagulants.

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The muscle fiber constant and the law of growth of the human ventricles Acetonitrile and propionitrile were highly effective aneuploidogens, inducing both chromosome loss and chromosome gain following brief exposures to low concentrations of these chemicals, and these nitriles also induced rapid paralysis. Six patients had aldosterone-producing adenomas (APAs) and five patients had nonfunctioning tumors.

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Clinicians should be aware that subdural hemorrhage can occur after PCI if no hemorrhage is noted in the initial head CT, and the operation should be performed as soon as possible when the consciousness level decreases. These results suggest that more than 0.9375 mg x kg(-1) of ropivacaine might be recommended to obtain sufficient postoperative analgesia for the ilioinguinal/iliohypogastric nerve block in children undergoing inguinal herniorrhaphy.

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Bridging the gap: a dental access initiative for Northland children. A polymorphism in the resistin gene promoter and the risk of coronary artery disease in a Chinese population. They analyzed the pre-ECMO data, ECMO course, and complications. Using cell culture ELISA as a cell surface receptor assay, we found that OGD produced a marked decrease in cell surface GABAA receptors, without altering the total amount of receptors.

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In summary, benign pyloric stenosis can be readily treated with endoscopic balloon dilation and should be the first-line therapy. Spontaneous IgM production from SLE B cells was inhibited by rTNF-alpha, but that from normal B cells was not. There is insufficient evidence to be able to say whether or not physical activity programs are beneficial for people with dementia. Prognostic factors for morbidity and mortality in elderly patients undergoing acute gastrointestinal surgery: a systematic review. A digital video photographic technique for esthetic evaluation of anterior mandibular teeth.

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Nociceptive behavioral responses (spontaneous pain and hyperalgesia) following bee venom (0.2 mg/50 microl) injection were assessed in adult male Sprague-Dawley rats receiving intrathecal administration of c-fos antisense oligodeoxynucleotide (ASO, 50 microg/10 microl), sense oligodeoxynucleotide (SO, 50 microg/10 microl) and saline (10 microl) 4 h prior to bee venom injection. Total synthesis of the cytotoxic enehydrazide natural products hydrazidomycins A and B by a carbazate addition/Peterson olefination approach.

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A critical element of response by the cardiac arrest team is initial airway management. Limited proteolysis with trypsin of smg p21B, a ras p21-like small GTP-binding protein having the same putative effector domain as ras p21s, produced the N-terminal fragment and the C-terminal tail of Lys-Lys-Ser-Ser-geranylgeranyl-Cys methyl ester.

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Pediatric heart re-transplantation has higher costs relative to benefits gained owing to shorter graft survival. Update: influenza activity--United States and worldwide, and the composition of the 1991-92 influenza vaccine. In this study, enzyme immunoassays for detection of type-specific antibodies to human immunodeficiency viruses (HIV) were developed by using short peptides corresponding to sequences located within the immunodominant domain of the transmembrane glycoproteins of both HIV-1 and HIV-2-simian immunodeficiency virus (SIV).

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Immunological investigations and histopathological analysis of sternoclavicular joint swelling confirmed the diagnosis of IgG type multiple myeloma. Determination of some essential amino acids in some raw and cooked Mexican foods A systematic and novel method for speculating and identifying the structures of alkaloids in M. The process of vision is impossible without the photoreceptor cells, which have a unique structure and specific maintenance of cholesterol.

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The organizational principles for the formation of a territorial medical support system for the Armed Forces In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The phenotype of VY1160 fragile Saccharomyces cerevisiae mutant is characterized by cell lysis upon transfer to hypotonic solutions and increased permeability of cells growing in osmotically stabilized media. Endpoints included progression-free survival (PFS), objective response rate, overall survival, and safety.