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We show that the Y chromosome has a very large pseudoautosomal region, which is followed by a heterochromatin block (HCY) separating the subtelomeric male-specific region from the rest of the chromosome. These data suggest that phy-induced phosphorylation of proteins such as PIF3 may represent the primary intermolecular signaling transaction of the activated photoreceptor, tagging the target protein for proteosomal degradation, possibly in nuclear speckles. The anionic adducts fall into two classes in regard to isotope exchange behavior in H(2) (18)O. carinii gp120 was purified from infected lungs by lectin affinity chromatography. Both of the disease-modifying compounds used in this study, MTX and GSTM, were able to reduce the slope of radiographic progression during 3 yr of follow-up.

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Fetal cardiac effects of doxorubicin therapy for carcinoma of the breast during pregnancy: case report and review of the literature. The glass-fiber post was placed into a root canal preparation under clinical conditions and documented. GC-MS libraries for the rapid identification of metabolites in complex biological samples. These findings stress the importance of positive maternal interaction behavior in at least some parts of regulatory adjustment of at-risk infants. Comparison of single dose kinetics of imipramine, nortriptyline and antipyrine in man.

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Published results, however, are from studies with relatively small numbers of patients. Site-directed mutagenesis identified the phosphorylation sites in Lcb4p as Ser(451) and Ser(455). Due to multiple DLTs occurring at the expanded MTD, the recommended phase 2 dose and schedule is paclitaxel (80 mg/m(2) over 1 h) and BMS-214662 (160 mg/m(2) over 1 h) administered weekly. A revised method for determination of serum mercaptalbumin and non-mercaptalbumin by high-performance liquid chromatography coupled with postcolumn bromocresol green reaction. An inhibitor of epidermal growth factor receptor kinase AG1478 did not affect angiotensin II-induced JNK activation cascade.

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This was associated with reduced sterol regulatory-element binding protein-1c and SCD mRNA levels. To evaluate the differences in the composition of gut microbiota in rat models under different nutritional status and physical activity and to identify their associations with serum leptin and ghrelin levels. Nature of stress and transgene locus influences transgene expression stability in barley. Gefitinib-induced interstitial pneumonia: A case report and review of the literature. Structural and functional modifications of phospholamban and regulation of calcium transport in the sarcoplasmic reticulum under conditions of metabolic cardiac insufficiency

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Thermally induced gelling systems have gained enormous attention over the last decade. GM-CSF-based cellular vaccines: a review of the clinical experience. In surface epithelia containing ciliated cells, the protein was associated with the microtubular structures responsible for ciliary movement.

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Today, the impact of the invasive olives on native vegetation and ecosystem function is of conservation concern, with European olive a declared weed in areas of South Australia, and African olive a declared weed in New South Wales and Pacific islands. We measured the area of the cerebral cortex in a longitudinal sample of 974 individuals aged 4-88 y (1,633 observations). Factors to consider in the delivery of quality services by hospitals.

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In patients with stage IVa-b NPC treated with IMRT, addition of induction chemotherapy to concurrent chemotherapy significantly improved 5-year OS and 5-year DMFS. The formation of caustics is an activated process, in which a measure of the intensity of the turbulence, termed the Stokes number St, is analogous to temperature in a chemical reaction: the rate of collision contains a factor exp(-C/St). This study reports some of the results of in-depth interviews with Health Care Workers in the Cape Coast municipality (Ghana) on their perception of risk of exposure to HIV, attitudes to known persons with HIV/AIDS, counselling and confidentiality.

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Membrane association of caveolin-1 is critical to this process and is facilitated by an atypical N-terminal membrane attachment domain (residues 82-101), termed N-MAD. Tobacco, alcohol intake, and diet in relation to adenocarcinoma of the esophagus and gastric cardia. We present a surgical telemanipulator system supporting long bone fracture reduction procedures.

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This Delphi study successfully identified key characteristics of patient position and operator position and motion for effective delivery of side-lying lumbar spine manipulations. Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. Postzygotic isolation varies by ploidy level within a polyploid complex.

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In Experiment 2, wild-type and Bcl-2 overexpressing males were castrated or sham castrated, implanted with testosterone-filled or blank capsules, and examined 12 weeks later. Imaging of spinal injury in abusive head trauma: a retrospective study. The response at electron fluences higher than 4 x 10(10) cm(-2) is supralinear, due to the increasingly relevant contribution of the high temperature peaks. Development of a new questionnaire to assess patient perceptions of cancer-related fatigue: item generation and item reduction. Oral coadministration of OVA/salbutamol after immunization with OVA efficiently suppressed both cellular and humoral responses to OVA.

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This paper looks at the steps in designing a zoological park that is universally accessible to all visitors. Assessment of heart rate, QT interval, and heart rate variability. Opacification of the cervical vertebral venous plexus was achieved by injecting contrast material into the upper part of the internal jugular vein while the lower portion of this vein was compressed externally with a tourniquet. Our analysis showed that several known breast tumor amplicons (at 8p11-p12, 11q13, and 17q12) are located within clusters of genes with correlated expression. The goal of these programs is to help students develop an independent research career and make important contributions in clinical and translational sciences.

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This article examines the requirements of EN 60601-1-4, which states that risk management is an integral part of the development of software for medical devices. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. However, the transfection of GlcNAc6ST-1 resulted in significant sulfate incorporation into CD44 and generated the 6-sulfo LacNAc/Lewis x epitope on CD44, which was present largely on N-linked glycans. In recent years, obesity and the metabolic syndrome have increased markedly in incidence and importance as a cause of hepatocellular carcinoma in some resource-rich regions.

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The fragment is not present in the DNA from Echinococcus multilocularis, Taenia hydatigena, Taenia saginata, Diphyll-obothrium latum, and Hymenolepis nana. In vivo treatment with a neutralizing dose of anti-OSM antibody inhibited the triglyceride dysregulation only until the synthesis of IL-6 and IL-11 began in the spleen (day 3). Their adverse effects remain the limiting factor for use on peripheral targets. The diagnosis and management of endocrine tumors causing hypertension in children. They would be accurate if the articular surface orientation was taken into account.

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Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. That signals derived from microbial rather than human elements may initiate PLE is supported by series of observations, including the PLE-protective effect of topically applied microbial-derived DNA repair enzymes. The peak height of an action potential produced by a short electrical impulse is dependent on the activation of tetrodotoxin-resistant ion channels. In addition, glucocorticoids induce differentiation of preadipocyte to adipocytes. The patient was a right-handed 56-year-old woman with a 26-year history of complex partial and secondarily generalized seizures.

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Latest research on a filterable element isolated from so-called pseudobotryomycoma. While both patients have since recovered from the virus and been released, the cases have raised awareness of the infectious threat of MERS-CoV, and they have put EDs and other frontline providers on heightened alert for patients with severe respiratory symptoms and other risk factors.

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Lamellar-to-cubic phase change in phospholipid bilayer systems incorporated with block copolymers: DMPC and PEO-PPO-PEO (P85). Multiple regression analyses tested the hypothesis that pain would be moderated by positive coping resources and mediated by negative coping resources.

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The importance of adapting the flowcharts to local epidemiology is highlighted. This study was designed to predict procedure successful rate and 1-year patency after carotid artery stenting (CAS) for carotid CTO using pre-procedural CTA. Clinical value of real-time tertiary fetal ultrasound consultation by telemedicine: preliminary evaluation. This study was designed to investigate the change in incidence and anatomic distribution of colorectal cancer in a population over a period of 15 years. A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

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STRA13 is a hypoxia-inducible bHLH transcription factor implicated in the pVHL/HIF, TGF-beta, and Jak/STAT pathways. In the other three patients appearance of the calculus was distant in time and was probably unrelated to their sarcoidosis. Our results suggest that menopause could represent an important concomitant cause in determining an impairment of exercise capacity.

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Three experiments, with old persons (59-80 years) and college students (17-30 years) in Experiments 1 and 2 and with college students (17-24 years) in Experiment 3, investigated the differences between two types of spatial location memory: memory for the location of individual items in an array and memory for occupied, as opposed to unoccupied, locations in an array. Can recurrent reflux disease after fundoplication be circumvented by adding a vagotomy? Semistructured questions guided the focus group and individual interviews. Congenital toxoplasmosis has a wide range of presentation at birth varying from severe neurological features such as hydrocephalus and chorioretinitis to a well appearing baby, who may develop complications late in infancy.

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Cyclin D1-induced proliferation is independent of beta-catenin in head and neck cancer. Long-term macroinvertebrate metric data from the Big Thompson and Cache la Poudre Rivers, Colorado, were collected at one site above, and three sites in and downstream from urban areas. Hb A(1c) values correlated well with total glycosylated hemoglobin in all three strains but were relatively lower than total glycosylated hemoglobin in diabetic DBA/2J mice. Neurite extension and in vitro myelination within three-dimensional modified fibrin matrices. Surugamides A-E, cyclic octapeptides with four D-amino acid residues, from a marine Streptomyces sp.: LC-MS-aided inspection of partial hydrolysates for the distinction of D- and L-amino acid residues in the sequence.

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Our study shows that C3d, and particularly the C3d/C3 ratio, provide sensitive markers for disease activity in SLE. We are investigating means of handling microparticles in microfluidic systems, in particular localized acoustic trapping of microparticles in a flow-through device. Irreducible traumatic dislocation of the hip caused by labral and capsular entrapment with a buttonhole effect Hypoglycaemia is a common side effect of insulin therapy in type 1 diabetes.

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A549 cells were transfected with synthetic EGFR sequence-specific siRNA by Lipofectamine. Effects of prototypic CYP enzyme selective inhibitors were characterized for each of the microsomal metabolic pathways. Our work reveals that cells in distinct clonal layers exhibit greater diversity in gene expression and greater transcriptional complexity than clonally related cell types in the central and peripheral axis. HEK293 cells stably-transfected with ABCA1 (HEK293-ABCA1) or non-transfected (control) cells were incubated with lipid free 125I-apoA-I for 24 hours. It is intimately involved in the pathogenesis of platelet-rich arterial thromboses.

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Network rigidity and metabolic engineering in metabolite overproduction. Measurement of mercury species in human blood using triple spike isotope dilution with SPME-GC-ICP-DRC-MS.

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While a distinct pattern of decreasing oxygenation with increasing distance from the tumor surface was observed for KHT tumors, striking intertumor variability was found in both spontaneous and first-generation transplants, with a reduced dependence on tumor volume. Nervous systems contain numerous amines and neuropeptides that function to both modulate the strength of synaptic connections and the intrinsic properties of network neurons. Mothers of low birthweight infants: breastfeeding patterns and problems. Study limitations and its implications on safety training design are also discussed.

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The right ovarian vein was found to be the essential source of thrombemboli which could not be stopped by the implantation of a Greenfield umbrella into the vena cava inferior. To determine how a condition of severe insulin deficiency affects mammary gland LPL activity and mRNA expression during late pregnancy, streptozotocin (STZ) treated (40 mg/kg) and non-treated (control) virgin and 20 day pregnant rats were studied.

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Electrophysiologic and functional characteristics of afferent impulses from the bladder Knock-out of endogenous IQGAP1 significantly increased the formation of nuclear YAP-TEAD complexes. Structure-activity relationships of pyrazole derivatives as potential therapeutics for immune thrombocytopenias. None of our patients showed signs of the so-called rubral tremor.

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