on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Epsin (Acyclovir)

Epsin helps treat pain associated with an outbreak of genital herpes after the sores heal. There is no cure for herpes, however, this prescription is a treatment that helps to decrease and ease symptoms of herpes infections. Epsin is am antiviral drug that belongs to a class of medications called "antivirals," or "antiviral medications." Your doctor may prescribe this drug as a treatment to relieve symptoms of your infection. This medication is similar to the drug valEpsin (Valtrex), which is another medication that may also be prescribed for herpes infections. This drug may cause serious side effects or mild side effects. This includes side effects that may affect the liver. Side effects that affect the skin as well as allergic reactions have occurred.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

Similar Products:
Ometab, Duloxetina, Renicin, Tambac, Remora, Flagystatine, Anamet, Obezita, Coumadin, Ledifos, Macox, Optamox, Ciprotan, Volequin, Myclin, Xiclav, Meganox, Nidagyl, Lomper, Ulcosan, Pinamox, Ketolef, Tadapox, Amodex, Sumetrolim, Unixime, Finalo, Primazole, Ixor, Rimox, Nefazan, Doneurin, Topictal, Cotrimoxazol, Zinacef, Herpex, Abacavir, Neuril, Mecir, Polypen,

epsin 1 protein

Effect of aging on the endothelial function of the penile corpus cavernosum in rats These findings support the concept of risk stratification to identify patients who may benefit from elective surgery. Sac I, Stu I, Alu I, Ssp I and Mbo I restriction enzymes were used for characterization of all the 14 IBDV isolates and four reference vaccine strains.

epsin 1 protein

To provide the reader with a basic understanding of the controversy surrounding population-based prostate cancer screening and of the tools needed to conduct early detection programs for prostate cancer among enrollees. All divisions were performed ex situ and provided a left split graft with only the LHV as the hepatic outflow.

epsin 1 protein

He is alive with no evidence of the disease 24 months after the operation. Further work is necessary to objectively characterize anxiety levels associated with induction of anaesthesia in this group of patients and parents. The diagnostic and treatment approach to two common conditions by the physician members of a community health maintenance organization. In this report, we characterize the structure and expression of Rh polypeptide genes in two D--homozygotes of Italian origin. No deleterious effects were noted when normal, PRFT treated, middle carpal joints were compared to contralateral untreated, normal joints.

epsin 1 protein

A major, yet poorly understood, feature of type 2 diabetes is the excessive hepatic glucose production and the corresponding insulin resistance leading to fasting hyperglycaemia. The results demonstrate that the postsynaptic effects of ACh are similar between SHR and WKY rat postganglionic neurons and, therefore, probably do not contribute to the observed differences in ganglionic transmission between SHR and WKY rat nerves. The problem of connecting solutions defined in different regions is basic for finite element formulations. Studies of the competition with a synthetic consensus sequence for the NF 1 recognition site have shown that the liver nuclear proteins, responsible for the formation of specific complexes with these fragments belong to the family of the nuclear factor 1 (NF 1). Parenteral nutrition in the septic patient: nitrogen balance, limiting plasma amino acids, and calorie to nitrogen ratios.

epsin 1 protein

In addition to a role in active maintenance, we found that the subsequent memory for the sample stimuli as measured by the post-scan subsequent recognition memory task correlated with activity in the parahippocampal gyrus during the delay period. Because the immune complex-forming reactants are not specific to any neural antigen, we propose that their effects are indirectly mediated by anaphylatoxins produced by activation of the complement cascade. The ratio of the rates of hydrolysis of 2 synthetic substrates, Z-Phe-His-Leu (ZPHL) and Hip-His-Leu (HHL), is characteristic for each type of ACE: somatic 2-domain 1, N-domain 4.5, and C-domain 0.7 (Williams et al, 1996). Detection of antigenic cyst wall elements in Colpoda inflata: an immunoelectron microscopic study and immunoblotting identification of cyst wall polypeptides. One of the current hypothesis for the molecular mechanisms of septic shock is that the enhanced NO production by mitochondrial nitric oxide synthase (mtNOS) leads to excessive peroxynitrite (ONOO(-)) production and protein nitration in the mitochondrial matrix, to mitochondrial dysfunction and to contractile failure.

epsin 1 protein

We apply the equation of Henderson Hasselbalch modified for polyelectrolytes and evaluate the changes in the electrostatic free energy starting from the pK curves as a function of the dissociation degree. Streptomycin in the treatment of miliary and meningeal tuberculosis based on a study of 30 cases.

epsin 1 protein

A panoramic radiograph was taken of 48 subjects with facial pain and 47 pain-free controls. These data give evidence that the peptides I and II act on the signaling pathways which are realized through Gs- and Gi-proteins. Utilization of chest and abdominal CT and TLS screening significantly increased, despite unchanged volume and severity of trauma patients during the study period. The diminished ductal development that occurs in response to loss of the IGF-I receptor is dramatically restored during pregnancy, whereas the ability of overexpressed IGF-I to protect mammary cells from apoptosis does not occur if the mammary gland is induced to undergo forced involution. Point of view of the French Society for Digestive Surgery on the Livre Blanc on cancer surgery

epsin 1 protein

Human papillomavirus detected in female breast carcinomas in Japan. Problems in radiological and histologic differential diagnosis and advantages of transsphenoidal approach besides indications are discussed. Scleroderma heart disease was a frequent cause of death among children with SSc.

epsin 1 protein

Mitochondrial DNA mutation in a Chinese family with myoclonic epilepsy and ragged-red fiber disease. The active site represents a cluster of positively charged residues located on an otherwise hydrophobic protein face.

epsin 1 protein

Two sources of information were used to design relevant mutations. These parameters, along with blood pressure, were monitored in these groups. Sick leave is related to frequencies of migraine and non-migrainous headache--The HUNT Study. Polarized distribution of gamma interferon-stimulated MHC antigens and transferrin receptors in a clonal cell line isolated from Fisher rat thyroid (FRT cells). Contrary to our initial hypothesis of the dlAVC as a control site, stimulation to this region resulted in the largest differential effects between stimulation types.

epsin 1 protein

The results have indicated that IBHV is a member of the avian adenovirus group. Intermittent angle-closure glaucoma in the presence of a white eye, posing as retinal migraine.

epsin 1 protein

Systemic administration of OPG prevented bone and cartilage degradation in vivo but had no effect on cartilage in vitro. EVH is superior to MIVH in terms of reduction in pain intensity, residual leg edema and saphenous neuropathy at seven days and again at three months postoperative.

epsin 1 protein

However, the procedure does not allow uniform extubation, and laryngotracheal reconstruction with costal cartilage may be too aggressive for neonates. Since the 1930s, psychologists have used 2 general paradigms for studying persistence in humans: the experimental paradigm and the cognitive/individual differences paradigm. Semantic processing in the right hemisphere may contribute to drawing inferences from discourse.

epsin 1 protein

We report on the case of a 61-year-old man with a soft tissue malignant myoepithelioma of the second toe of the right foot. The significance of antibody cytophilic for macrophages in typhus infections is discussed. In leukemia with DIC, hyperfibrinolysis and marked bleeding symptoms are often observed. Rather, neurofeedback effects seem to be based on the modulation of response inhibition processes in medial frontal cortices. Neural substrates of classically conditioned fear-generalization in humans: a parametric fMRI study.

acyclovir treatment of shingles

  • hsv encephalitis acyclovir dose herpes
  • acyclovir de 800 mg dosis font
  • acyclovir herpes prevention dose
  • acyclovir 200mg capsule apo
  • acyclovir drug mechanism of action
  • herpes acyclovir pregnancy category
  • viral meningitis treatment acyclovir dose for herpes
  • acyclovir overdose in dogs
  • acyclovir 800mg best drug to treat herpes
  • acyclovir negative effects
  • zovirax acyclovir side effects
  • epsin 1 protein
  • traitement zona acyclovir dosing
  • acyclovir in pregnancy last trimester
  • acyclovir side effects in pregnancy
  • acyclovir gengar 800 mg para sirve
  • acyclovir 800 mg comprimidos de cafe
  • acyclovir resistant hsv encephalitis treatment for dogs
  • tromantadine vs acyclovir 200
  • acyclovir animation vs animator
  • mucomyst drug action of acyclovir
  • valacyclovir vs acyclovir efficacy vs efficiency
  • comprimido acyclovir uses
  • prevent cold sores acyclovir dosage
  • acyclovir liquid
  • sediaan acyclovir syrup
  • valgan acyclovir dosage
  • biochemistry and mechanism of action of acyclovir uses
  • herpes acyclovir iv dosing
  • acyclovir tabletas 400 mg dosis recomendadas
  • acyclovir iv dose encephalitis
  • levodopa drug action of acyclovir
  • compounding acyclovir ointment for shingles
  • oral acyclovir cold sore dosage
  • acyclovir shingles treatment dosage
  • acyclovir dosage for ocular herpes simplex
  • acyclovir de 800 mg contraindicaciones de la
  • varicella zoster treatment acyclovir dose for cold
  • carafate drug action of acyclovir
  • dosing of acyclovir for bell's palsy
  • acyclovir dose pediatrics
  • acyclovir 400 mg directions map
  • acyclovir dose for herpes prophylaxis treatment
  • acyclovir 5 ointment reviews
  • varicella decorso con acyclovir and alcohol
  • what's this for acyclovir 400 mg
  • acyclovir syrup india
  • keppra loading and maintenance dose for acyclovir
  • fuegos en los labios acyclovir medication
  • dose acyclovir injections
  • acyclovir 800 mg espanol noticias
  • tromantadine acyclovir and alcohol
  • acyclovir 800 mg dosaggio ormonale
  • cold sore treatment acyclovir dosage in children
  • acyclovir tablet price in india
  • cvs acyclovir ointment for shingles
  • acyclovir 200 mg adalah dan
  • acyclovir price in mercury drug logo
  • acyclovir tablets 800 mg
  • atypical drug action of acyclovir
  • acyclovir treatment of shingles
  • herpes meningitis acyclovir dose for genital herpes
  • salep herpes selain acyclovir medication
  • xefo drug action of acyclovir
  • herpes esophagitis acyclovir dose pediatric
  • pomata herpes acyclovir ointment
  • acyclovir price in pakistan a300f
  • 6 deoxy acyclovir uses

biochemistry and mechanism of action of acyclovir uses

Gamma-p-toluenesulfonyl-alpha,beta-epoxysilane: a new and practical acrolein beta-anion equivalent. These results, in conjunction with evidences of clinical effectiveness and cost benefits demonstrated in the same sample of patients, strongly support the use of telerehabilitation to improve access to rehabilitation services and efficiency of service delivery after TKA.

herpes meningitis acyclovir dose for genital herpes

Whereas the nu(C-H) frequencies represent an average conformational order along all the alkyl chains present, by following changes in nu(C-D) vibrations, mobility of those membrane domains deuterium labeled at specific depths in the hydrocarbon core can be estimated. For the separation and conditions considered the new eremomycin CSP revealed a better performance compared to the teicoplanin CSP. The chance for fertility in adolescent boys after corrective surgery for varicocele. Subclinical hyperthyroidism (SH) has been associated with exercise intolerance, changes in cardiac morphology, atrial arrhythmias and sympathovagal imbalance.

acyclovir liquid

The best agreement for percent Gleason grade 4/5 was in 2 pathologists at the same department (weighted kappa 0.86). The nodule was drained and culture of the purulent material yielded Streptococcus viridans. Results indicated that the predictive ability of self-assessed health for mortality was greater in men with tertiary education as compared with the lowest educated men. CRISPR System Acquisition and Evolution of an Obligate Intracellular Chlamydia-Related Bacterium.

acyclovir iv dose encephalitis

The different fractions obtained have been reannealed to a Cot value of 20 mol times sec/1 to study the distribution of the intermediate DNA on the MAK column. The model also predicted that afferent stimulation evoked transient hyperpolarization of ramp-inspiratory (ramp-I) neurons. Moreover, it assumed that the slice profile of an MPR image became a convolution of the square profile corresponding to the nominal slice thickness and line spread function (LSF) of an axial image, and the simulation was performed. Further analyses demonstrated that HIV-1 could finish the first round of replication in CEM.NKR cells, but the released virions were poorly infectious. Herein the pertinent literature on fungal urinary tract infections is reviewed, with emphasis on the predisposing factors, pathogenesis, host defense mechanisms and the clinical spectrum of the disease.

comprimido acyclovir uses

Secretagogue action of adenosine in the in vivo canine tracheal mucus model. It is an opportune time for radiologists to focus on personal productivity.

acyclovir side effects in pregnancy

Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts. BET 3: Bedside lung ultrasound for the diagnosis of pneumonia in children. Diffusion-weighted magnetic resonance imaging of cerebrospinal fluid in patients with and without communicating hydrocephalus. The hematological picture persisted despite antibiotic therapy and recovered only after surgical removal of the vegetations, tricuspid and pulmonary valvectomy, and patch closure of the ventricular septal defect.

varicella decorso con acyclovir and alcohol

A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. This leads to improved performance in the daVinci surgical platform on simulated tasks. Although ordinarily single-stranded DNA binding protein (SSB) prevents filament nucleation, single RecA monomers can easily be added to an existing filament and displace SSB from DNA at the rate of filament extension. However, cyanophycin appeared to play a less important role in the non-diazotrophic unicellular strains and phycobilisomes appeared to be the main nitrogen reserve. Alterations in nuclear morphology and the formation of euchromatin were absent or reduced at the same time intervals examined in diabetic animals.

acyclovir 800 mg comprimidos de cafe

Evidence of doping-dependent pairing symmetry in cuprate superconductors. These same animals were able to perform as well as controls on discrimination tasks based on either place or visual (light-dark) cues, although they made more errors than controls in reaching criterion in the initial place discrimination problem.

acyclovir 200 mg adalah dan

The group treatment contained elements of victim empathy, cognitive restructuring, sex education, assertiveness and social skills, education about sex offender therapy, and a discussion of the possible consequences of continued denial. (Re-)construction of infertility in the age of reproduction medicine Lingual tipping and extrusion of the anterior dentition occurred with both archwires. On hospital day 4, the frequency of diarrhea decreased to approximately 5 times per day, and the right flank pain resolved. Studies of the fish rhabdovirus DNA vaccines have elucidated factors that affect DNA vaccine efficacy as well as the nature of the fish innate and adaptive immune responses to DNA vaccines.

zovirax acyclovir side effects

Person-Centered, Physical Activity for Patients with Low Back Pain: Piloting Service Delivery. In a competition assay, fluid-phase flvWF appeared to inhibit efficiently the binding of Factor VIII to immobilized vWF isolated from plasma, whereas vWFdelpro did not influence Factor VIII binding.

acyclovir resistant hsv encephalitis treatment for dogs

Identification of a resistance gene to bacterial blight (Xanthomonas oryzae pv. In this vein, biomolecular self-assembly has emerged as an efficient approach for building synthetic nanostructures from the bottom up.

acyclovir gengar 800 mg para sirve

Series of incidents of Listeria monocytogenes non-invasive febrile gastroenteritis involving ready-to-eat meats. With the use of HCT116 colon carcinoma cells, a total of 305 basic and 183 acidic proteins was identified.

acyclovir shingles treatment dosage

Changes in gait patterns due to a simultaneously performed cognitive task have been reported previously and associated with an increased falling risk among older adults. In addition, we proposed a new risk classification and evaluated its usefulness. In a cohort of 18 patients undergoing SVC resection for malignancy and major vein reconstruction, 7 patients underwent ligation of the LIV with no neurological symptoms. This research will provide systems for the investigation of mechanisms in liver development and establish a method of ES cell-based therapy for liver diseases. A pilot exome-wide association study of age-related cataract in Koreans.

acyclovir price in pakistan a300f

We investigated the effect of spinal cord stimulation (SCS) on heart rate variability (HRV) and evaluating its influence on the sympathetic/parasympathetic balance in chronic pain. 100 of chronic active hepatitis in France and constitute a major cause of cirrhosis. Nutritional and toxicological assessment of white-rot fermented animal feed. Preoperative perhexiline does not improve myocardial protection in patients undergoing coronary surgery and in fact reduced perioperative cardiac output, increasing the need for inotropic support. Toxicity of human serum and bovine serum for leukocytes of guinea pig

compounding acyclovir ointment for shingles

Detection of gelatinolytic enzyme activities after sodium dodecyl sulfate-electrophoresis and protein blotting. A comprehensive dictionary of protein accession codes for complete protein accession identifier alias resolving. Because bone marrow and spleen produce inhibin and activin, our aim was to evaluate their possible effect on cell-mediated immune function. Although betamethasone (0.012 mg ear(-1) day(-1)) showed similar activities to olopatadine against these responses, it caused atrophy of the ear skin. Several clinical studies have begun to unravel the pathophysiologic diversity of hypertensive patients as well as the heterogeneity of their cardiovascular disease.

6 deoxy acyclovir uses

The operational specifications for the controller are represented by utility functions, and the corresponding resource management problem is formulated as a safety control problem. Motivation, vocational interests and job satisfaction of mentally retarded adults. The design trade-offs are discussed, and the sensitivity and measurement range are presented. A 62-year-old woman had a malignant polypoid lesion which completely occluded the introitus of the right main bronchus and deviated to the introitus of the left main bronchus. A survey was conducted to better understand the training needs of faculty members without dental public health (DPH) specialty board certification who teach DPH to dental students.

salep herpes selain acyclovir medication

Moreover, they further refine the complex and serial roles of the C/EBP family of transcription factors in inducing and maintaining the metabolic properties of mature adipocytes. Among the malignant tumors, LOH for loci on chromosome 10 occurred in 2 of 4 morphologically malignant tumors and in 2 of 4 morphologically and invasively malignant tumors. The effects of temporary agency work contract transitions on well-being. Retro-priming, priming, and double testing: psi and replication in a test-retest design. Construction of nondefective adenovirus type 5 bearing a 2.8-kilobase hepatitis B virus DNA near the right end of its genome.

acyclovir de 800 mg dosis font

The underivatized FVFA are then directly separated by gas chromatography. Such an effect might be particularly relevant to clinical situations in which this receptor is overexpressed, such as in certain neoplasms. Natural phytochemicals and their derivatives are good drug candidates for anticancer therapeutic approaches against multiple targets.

 Show Hide 
valacyclovir vs acyclovir efficacy vs efficiency 2019-11-17

In sorting tasks, participants were more likely to sum characteristic features and form LS categories with social materials. Equation-based triangle orientation discrimination sensor thuoc klamentin 625 mg welchol performance model based on sampling effects.

acyclovir 800 mg dosaggio ormonale 2017-08-27

The model considers the blood as a suspension of particles in plasma, accounting for cell-cell and cell-wall interactions to predict colegio padre zegerid otc coupons macroscopic blood rheology. The various methods are compared as to which is best suited for which purpose. Global Human Appropriation of Net Primary Production for Biomass Consumption in the European Union, 1986-2007.

acyclovir dose for herpes prophylaxis treatment 2011-04-18

Compared to composting systems, bioreactors have the major advantage of a short treatment time, but the disadvantage of being more labour intensive and more expensive. Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Two hundred patients with normal coagulation status undergoing routine diagnostic cardiac catheterization were randomized to intravascular sheath access versus guidewire access groups. Contralesional neglect in monkeys with small unilateral parietal cortical ablations. Our study is the first to demonstrate the antioxidant and antimicrobial properties ribavirin mechanism of action animation full of wild British Columbia roses.

acyclovir treatment of shingles 2016-11-03

Here, we describe two independent models of cardiac preconditioning in the adult zebrafish. Transcription factors are cellular proteins that can up-regulate or down-regulate the transcription of genes and offer promising therapeutic targets. Nutritional quality of a product or preparation is associated with formulation/recipe and not with the level of processing, with few exceptions. Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. There was a more than 6000-fold difference between the LD50 values of the Cry protein mixture with lanso tad 30 mg nebenwirkungen almased the lowest larvicidal activity and the mixture with the highest larvicidal activity.

mucomyst drug action of acyclovir 2013-10-05

Current practice is assessment using the lansoprazole 30 mg obat untuk apa lagi modified triple test (MTT). A toxicologic and dermatologic review of nerol when used as a fragrance ingredient is presented. To examine the frequency of psychiatric disorders before and after surgery for epilepsy and the postoperative changes. Painful regional anaesthesia induces an immunological stress reaction: the model of retrobulbar anaesthesia.

levodopa drug action of acyclovir 2011-05-07

This procedure represents a viable option for patients in whom a standard, less complicated arthrodesis cannot be performed. ILA might be indicated in earlier stages of ARDS following a multimodal treatment approach. Here, we report that 15d-PGJ(2) induces DR5 brand names omeprazole expression at both mRNA and protein levels, resulting in the synergistic sensitization of TRAIL-induced apoptosis in human neoplastic cells, such as Jurkat human leukemia cells or PC3 human prostate cancer cells. This work establishes a Dps-mediated link between light tolerance, H2O2 detoxification, and iron homeostasis, and provides further evidence on the non-redundant role of multiple Dps proteins in this multicellular cyanobacterium.

acyclovir 200 mg adalah dan 2015-05-18

A total of 8553 rural and 8909 urban residents participated in this provincial survey. logical and reporting problems were widespread, including failure to report full results, missing population details, multiple testing, and over-reliance on subgroup analysis. In this study, the biosynthesis and glycosylation of hepatic gp130 were investigated using a specific polyclonal antibody to the 287 amino acid cytoplasmic domain of gp130. Taken together, these results provide evidence that oncogenic H-Ras activates DNA repair capacity through the Ras/PI3K/Rac1/NADPH oxidase-dependent pathway and that increased ROS production via this signaling pathway is required for enhancement of the DNA repair capacity induced by oncogenic H-Ras. We also showed by Northern blot analysis that both the 1.1-kilobase and 1.5-kilobase NT/NN precursor messenger RNAs were present in the rMTC 6-23 cell line and that the time course and dose response of dexamethasone-induced messenger RNA synthesis were in good agreement with those observed for dexamethasone-induced increase drug interaction escitalopram pregabalin in processing products.

cold sore treatment acyclovir dosage in children 2010-10-23

The effects of phenobarbital (PB) and other liver monooxygenase modifiers on dimethylnitrosamine (DMN)-induced alkylation ucerax syrup recipes of rat liver DNA and protein were investigated at different carcinogen doses. Peripheral neuropathy and multiple myeloma in aging: a case report. In addition, noggin may have potential as a novel molecular and diagnostic marker for identifying certain types of schwannoma. Gouging injuries represent a rare, severe form of orbital trauma.

acyclovir negative effects 2018-11-29

The results suggest that the elevation of blood pressure induced by i.c.v. Numerical calculations reveal that the fractal dimensions of noise-induced SNAs typically assume fractional values, in contrast to SNAs in quasiperiodically driven systems whose dimensions are digoxin dosage forms of spironolactone integers. Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Application of fuel cell technology to health care institutions in rural and urban environments. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.