A new adult dosing regimen of Glamin has been approved. Glamin is an antibiotic used to treat various respiratory-tract infections, including sinusitis, bronchitis, and pneumonia. In the new regimen, Glamin is administered twice a day (BID), every 12 hours, in contrast to three-times-a-day regimen used since Glamin was introduced in the United States. The BID regimen for more severe infections and infections of the respiratory tract consists of a new tablet containing 875 mg of amoxicillin and 125 mg of clavulanate potassium. In addition, the currently marketed tablet containing 500 mg of amoxicillin and 125 mg of clavulanate potassium can now be prescribed on a twice-a-day regimen for less severe infections that may be treated with a lower dose. Glamin should not be used in subjects with a history of allergic reactions to any penicillin or with a previous history of Glamin-associated cholestatic jaundice/hepatic dysfunction.
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WS has a characteristic neurocognitive profile that includes intellectual disability (ID). Evidence including live-cell imaging and isobologram analysis indicated that targeting KIF11 and Aurora A together promoted monoastral efavirenz child dose pepto spindle formation and mitotic catastrophe synergistically, supporting a model of parallel pathways of centrosome regulation by Aurora A and KIF11.
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