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Griseofulvin has long been considered the agent of choice for the pharmacotherapy of tinea capitis. It has an established efficacy and safety profile, and it is relatively inexpensive. Griseofulvin is FDA-labeled for use in children aged 2 years and older, and it is available as an oral suspension (25 mg/mL) and as a tablet, which may be crushed and administered over soft foods without chewing. Oral absorption of Griseofulvin differs by product. Absorption of ultramicrosize products (Gris-PEG, 125 mg, 250 mg tablets) is nearly complete, whereas absorption of microsize products (Griseofulvin V suspension and 500 mg tablets) is less, approximately 25% to 70%. Administration of microsize Griseofulvin products with fatty meals can increase absorption because it is lipophilic. These differences in absorption result in differing dosing: 10 mg/kg per day to 20 mg/kg per day for microsize products and 5 mg/kg per day to 15 mg/kg per day for ultramicrosize products, both given for 6 to 8 weeks’ duration. Some experts recommend that treatment durations of up to 12 weeks may be necessary. Griseofulvin may be given in one or two divided doses per day. Some experts recommend Griseofulvin dosages as high as 25 mg/kg per day (microsize), as anecdotal evidence indicates that higher doses may be necessary. The 2009 AAP Red Book recommends that treatment be continued for 2 additional weeks beyond clinical resolution.

Other names for this medication:
Griseofulvin, Grifulvin, Fulcin, Fulvicin, Fulviderm, Fungistop, Grifulin, Grisetin, Griseofulvina,

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