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YKL-1001 induced both cytopathic effects exclusively in AFP-positive liver cancer cells and the growth inhibition of pre-established Hep3B xenografts. Glenohumeral arthroplasty for arthritis after instability surgery. The process of exercise-induced adaptation in skeletal muscle involves a multitude of signalling mechanisms initiating replication of specific DNA genetic sequences, enabling subsequent translation of the genetic message and ultimately generating a series of amino acids that form new proteins. The addition of a second, posteromedial graft reduced laxity in this flexion range but did so at the expense of higher-than-normal forces in the posteromedial graft.

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Tissue expression of selected RNA was performed by microarray analysis and validated using qRT-PCR. Competing stochastic models of the incubation period: an investigation of age-at-diagnosis of familial and sporadic retinoblastoma. This study prospectively evaluated the predictive value of serum uric acid (SUA) levels for mortality after angiographic diagnosis of CAD. Compression implants: case report of a surgical, prosthetic, and cosmetic failure.

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Data were collected from two internal data sets from 2008 to 2012 for general medicine and intensive care unit patients. Twelve rats were sacrificed each week from 32 to 81 days of age. An abnormal signal-averaged ECG (SAECG) has predictive value for arrhythmic events in patients with coronary artery disease. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract.

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Molded Parallel Endografts for Branch Vessel Preservation during Endovascular Aneurysm Repair in Challenging Anatomy. Hence, the symbiotic bacteria benefit the growth of their hosts, perhaps by supplying essential factors that are adequate even in a rich blood medium. Drug addiction is a multileveled behavior controlled by interactions among many diverse neuronal groups involving several neurotransmitter systems. Motor neuron disorders (MNDs) are a clinically heterogeneous group of neurological diseases characterized by progressive degeneration of motor neurons, and share some common pathological pathways.

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Previous reports have only differentiated against one of these mouse light chains. In patients with short stature-especially when clinical features are accompanied by vascular complications-MOPD II should be considered as a differential diagnosis leading to consecutive genetic testing. There is conflicting evidence on the relative risk of prostate cancer in men with schizophrenia.

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This fraction inoculated into mice protects against experimental infection. Source analyses revealed that the superior temporal gyrus in both hemispheres is involved in ASTM.

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The cotton rat (Sigmodon hispidus) is susceptible to human adenovirus infection, permissive for viral replication and exhibits similar inflammatory pathology to humans with adenovirus replicating in the lungs, respiratory passages and cornea. The clinical significance of such changes remains poorly characterized. New research into possible treatment options has been inspired by increased understanding of the pathophysiology of psoriasis and advances in immunology and molecular biology permitting the development of targeted, highly active biologic agents. The geographic distribution of multiple sclerosis (MS) in Sweden over time was compared in order to analyze homogeneity. Spectral analysis of hematin indicated that a higher oxidation state of hematin iron may be transiently formed during reaction with hydroperoxides and accounts for the propagation of lipid peroxidation when reactions proceed in the presence of soybean phosphatidylcholine liposomes.

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Clinical and CT parameters provide a promising tool to effectively identify patients at high risk of pneumothorax following endoscopic valve therapy. The results of noninvasive diagnostic tests and the clinical variables potentially associated with excellent surgical outcome were examined in patients with a minimum follow-up of 1 year (mean follow-up, 9 years).

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In mice, administration of kainic acid, an analogue of the excitotoxin glutamate, results in hippocampal cell death and seizures. Subsequent bone marrow biopsy with flow cytometry confirmed AML with myelodysplasia-related changes. The ability of Marburg (and control) alpha chains to serve as a substrate for factor XIIIa and undergo cross-linking was examined in an in vitro plasma clotting system. To probe into the curative effect and mechanism of action of the Houpu Mahuang oral liquid (HPMH) in treating bronchial asthma. However, the potentiation after in vivo administration of ethanol plus nitrendipine was significantly greater than after ethanol alone.

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Pharmacokinetic characteristics and biodistribution of radioiodinated chimeric TNT-1, -2, and -3 monoclonal antibodies after chemical modification with biotin. Although the best of these T-state inhibitors only has a K(i) value in the micromolar range, the structural information with respect to their mode of binding provides important information for the design of second generation inhibitors that will have even higher affinity for the active site of the T state of the enzyme. Genome sequencing studies have shown that human malignancies often bear mutations in four or more driver genes, but it is difficult to recapitulate this degree of genetic complexity in mouse models using conventional breeding. The serum ammonia level in peripheral blood was within normal limits, which suggests the presence of a homeostatic control mechanism.

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Changes of enzyme activities in the myocardium and skeletal muscle fibres of cardiomyopathic hamsters. Data on time to mortality, mortality rate, time to hatching, hatching rate, skeletal malformations rate, and larval standard length were registered until 8 days post-fertilization. A ganglioside fraction was extracted and purified and the amount of each component ganglioside was assessed by thin-layer chromatography.

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SDZ RAD and MMF caused significant side effects including compromised wound healing and bone marrow suppression culminating in weight loss and death. Dysbindin is associated with alpha-dystrobrevin, a component of the dystrophin-glycoprotein complex (DGC) in muscle. Since nse2.SA cells are sensitive to DNA-damaging agents and to exposure to hydroxyurea, this implicates the Nse2-dependent sumoylation activity in DNA damage responses but not in the essential function of the Smc5-6 complex. Mass spectrometry and infrared spectroscopy measurements have shown that the major components of gas-phase chemicals emitted from natural paint are monoterpenes including alpha- and beta-pinenes, camphene, p-cymene, and limonene. A randomized controlled trial of the effectiveness of a self-help psychoeducation programme on outcomes of outpatients with coronary heart disease: study protocol.

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To improve the computer connectivity and network strategies to connect U.S. Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation.

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To evaluate the feasibility of concurrent weekly Cis-platinum chemoradiation (CRT) in the curative treatment of primary vaginal cancer. Established databases and published reports were used as data sources. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program in human cancer cells and in murine B cells.

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At the behavioral level, most studies indicate a reduction in space use and movement and higher frequencies of disturbances, which has been linked with a higher frequency of scratches and decline in carcass quality. Determination of kinetics parameters of the main glow peaks for KMgF3:Lu and LiF:Mg phosphors after long-term high temperature storage. Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle. Class discovery analysis of the lung cancer gene expression data. In the absence of arguments that clearly demonstrate irrevocable harm from nondisclosure and against a backdrop of arguments that compellingly highlight the potential for serious harms from disclosing incidental findings of nonparentage, we advocate for a universal, institution-wide policy of nondisclosure.

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The relative genetic potencies of the two compounds were deduced from regression studies of the dose effect on the metabolically inert sperm and the metabolizing early germ cells (spermatocytes and spermatogonia) with respect to the induction of the non-specific X-chromosome recessives (lethals and visibles) and the specific effects on representatives of the RNA genes, especially rDNA. Ampicillin showed the highest affinity for PBPs 1a or 1b, or both, and also PBPs 3a or 3b, or both. These findings have important implications for our understanding of cell mechanics and mechanotransduction as well as interpretation and modelling of pipette aspiration data.

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Whereas the vertebrate muscle myosin heavy chains (MHCs) are encoded by a family of Mhc genes, most insects examined to date contain a single Mhc gene and produce all of the different MHC isoforms by alternative RNA splicing. ON THE INCREASE IN OXIDATION IN THE EGG AT THE BEGINNING OF DEVELOPMENT. Infusion of EPO at a dose of 5 U/day prevented the occurrence of ischemia-induced learning disability. Therefore, the authors tested the utility of implementation intentions--specific plans linking a behavioral opportunity to a specific response--in reducing automatic bias.

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These results implicate light-dependent, PHYC-mediated activation of PPD1 expression in the acceleration of wheat flowering under inductive long days. At 2, 4, 8, 12, 20, and 28 weeks, functional assessment of nerve regeneration was performed using walking track analysis.

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Regional deafferentation down-regulates subtypes of glutamate transporter proteins. The Diabetes Continuity of Care Scale: the development and initial evaluation of a questionnaire that measures continuity of care from the patient perspective.

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However, relatively few studies have tried to isolate the specific stage(s) of information processing affected by smoking/nicotine. Now, efforts in the field are directed at understanding the roles in plastid transcription of each member of the rapidly expanding plant sigma factor gene family. The increased prevalence of obesity in children and its complications have led to a greater interest in studying baroreflex sensitivity (BRS) in children. pulmonis was enhanced by pretreatment of the mice with progesterone.

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Comparative study of DNA damage, cell cycle and apoptosis in human K562 and CCRF-CEM leukemia cells: role of BCR/ABL in therapeutic resistance. Effect of Extracellular Factors on Growth and Dimorphism of Rhizopus oryzae with Multiple Enzyme Synthesizing Ability.

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False-positive stress PET-CT imaging in a patient with interstitial injection. Altered immune cell proportions in the radiodermatitis induced hairless mice-1 (HR-1). Electroencephalographic findings in patients with major depressive disorder during cognitive or emotional tasks: a systematic review. Multiple stressors, physical and psychological, may beset intensive care unit patients.

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Using an anti-alpha 1-ACT polyclonal antibody, we detected a 62 kDa immunoreactive band both in cultured human myogenic cells (mononucleated myoblasts as well as multi-nucleated myotubes) and in extracts of human muscle biopsies. At low doses, acrolein inhibits cell proliferation without causing cell death and may enhance apoptosis from secondary toxins, while at higher doses oncosis ensues.

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Despite the relatively known intracellular signaling pathways involved in the synergistic induction of inflammation, it is still unclear if both bacterial pathogens also synergistically induce expression of surface TLR2. The percentage of cells exhibiting strong staining was estimated both for breast carcinoma and for all adenocarcinomas as a group. We analyzed patterns of mtDNA and Y chromosome variation in the Gilaki and Mazandarani. Aminoalkyl adenylates and aminoacyl sulfamates derived from arginine, histidine and threonine, have been prepared and tested as inhibitors of their cognate Staphylococcus aureus aminoacyl tRNA synthetases.

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Precision of titration of poliomyelitis virus infectivity in tissue cultures. Antiviral Activity of Total Flavonoid Extracts from Selaginella moellendorffii Hieron against Coxsackie Virus B3 In Vitro and In Vivo. Use of integrated test programs for complex veterinary control of the milking technic.

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To benefit from the high spatial and temporal resolution of the respective dynamic MRI data sets, their analysis requires algorithms that are capable of both precisely delineating task-related activation patterns and demonstrating functional connectivity of interacting areas. The effects of different doses of ondansetron (0.1, 0.5, 1, 2 mg/kg) administered intra-peritoneally were studied on amphetamine-induced hyperactivity and stereotypy in wistar rats. Moreover, the relationship between FM indicator and mortality was monotonic increasing and the relationship between FFM indicator and mortality was monotonic decreasing.

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The present findings reveal that oxytocin not only enhances cell proliferation, but also promotes the development of the new neurons which is associated with the induction of positive emotional and social behaviors. The study protocol permitted crossover of patients to the alternate treatment arm under stringent conditions. Pectin methylesterase and pectin remodelling differ in the fibre walls of two gossypium species with very different fibre properties.

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In this study, a heterotrophic denitrifying community from sediments of a marine intertidal flat active in nitrogen cycling was selected in a chemostat and monitored over a period of 50 days. Since IFN-alpha has been shown to limit VZV replication in human skin xenografts, the ability of VZV IE63 to block the effects of the cytokine may play a critical role in VZV pathogenesis. Functional consequences of familial hemiplegic migraine mutations point to an important role for cortical spreading depression in migraine pathophysiology.

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Chemonaive patients with stage IIIB/IV NSCLC received gemcitabine 1,250 mg/m(2) (days 1 and 8) plus cisplatin 80 mg/m(2) (day 1) every 21 days. The effect of methanol on lipid bilayers: an atomistic investigation. The provenance of this structure and its mode of formation are unknown. Pharmacokinetic data observed in advanced renal failure (creatinine clearance between 10 and 30 ml/min) are similar to those observed in healthy subjects or patients with normal renal function.

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The typical clinical manifestations of diffuse large B-cell lymphoma (DLBCL) included nasal obstruction, rhinorrhea, bleeding in nose, headache,etc. The levels of cytidine deaminase and cytosine deaminase activities were lowered after growth on cytidine or deoxycytidine as a nitrogen source instead of ammonium sulfate. By way of these findings, the better biocompatibility of PVA-H was documented.