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GM2 activator protein (GM2AP) is a cofactor for stimulating the enzymatic hydrolysis of the glycolipid GM2 by beta-hexosaminidase A to produce GM3. Based on previous reports, we hypothesized that the arginine in framework 1 (FR1) of the VH might interfere with translocation to the periplasm by means of the signal peptide. These results indicate that Fah(-/-) rats may be used as an animal model of HT1 with liver cirrhosis.

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The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. The fast delivery of the 6F beam is not only beneficial in stereotactic radiosurgery of a single brain lesion, but also for treating multiple brain lesions (2-12 lesions in this study group). This review focuses on the new approaches and concepts that are being developed to tackle these challenging targets: the use of fragment based methods to explore the chemical space, stapled peptides to regulate intracellular PPI, alternatives to competitive inhibition and the use of antibodies to enable small molecule discovery for these targets. Our paper suggests that a simple battery, which can be performed in 5/10 min, can be easily applied and provides useful information on various aspects of early neonatal visual function.

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However, the actual mutations responsible for these muscular hypertrophy phenotypes in sheep have yet to be identified, and further characterization of the genetic basis for these phenotypes will provide insight into the biological control of muscle growth and body composition. Presence of the 55 kDa glycosylation inhibiting factor in human serum. In contrast, SHEPrSNS-0322000nM, the SNS-032-resistant sub-line of the neuroblastoma cell line SHEP, displayed low level SNS-032 resistance also when ABCB1 was inhibited. We hypothesize that intrinsic properties of the muscles predict spring-like behavior of the jaw elevator muscles during opening and fast close phases of the jaw cycle and that modulation of stiffness by the central nervous system leads to spring-like properties during the slow close/power stroke phase.

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Effect of lamellar flap location on corneal topography after laser in situ keratomileusis. The magnitude of the expression of the Ad-tob gene in cancer is correlated to tumor suppressive activity. Painful neuropathies have multiple disguises and may to a certain extent be mimicked by non-neurological pain conditions.

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Influence of chain length on exciton migration to low-energy sites in single fluorene copolymers. It is often difficult to predict at the time of a bowel resection whether or not a short bowel syndrome will occur postoperatively. Interaction of the Tramtrack protein from Drosophila melanogaster with DNA was analyzed by a cross-linking method.

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This article describes the basic facts, features, and dynamics of school violence and presents a prevention, response, and recovery protocol adapted from the related field of workplace violence. High-Dimensional Longitudinal Genomic Data: An analysis used for monitoring viral infections. An increase in lipid peroxidation intensification in preeclamptic placentas leads to an increased level of lipid peroxidation products and increased reactive oxygen species activity which can be associated with increased activation of chemicals to electrophilic species that bind covalently to DNA and form adducts. Degradation of omeprazole depends on the amount of acidic groups in the polymer structure. The distribution of milk components and milk yield during lactation, and changes of the absolute and relative energy amount in the different milk components were calculated and evaluated.

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serial T2-weighted images of rotator cuff muscles were obtained before pitching (or shoulder exercise) and immediately, 30, 60 min, 24, 48, 96 hrs after pitching (or shoulder exercise). Effects of dietary protein, lipotropic factors, and re-alimentation on total hepatic lipids and their distribution.

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Sensitivity analysis using M5 model tree also suggests that its results reflect the physical conditions. We think that indications for thoracoscopic surgery will expand in developing these techniques in the future, if thoracoscopic surgery is safer and more efficient. Transcranial magnetic stimulation (TMS) is a non-invasive, well tolerated technique to interfere with cortical neuronal activity with high temporal and fair spatial resolution. We examined the safety and efficacy of dofetilide in this setting through a retrospective chart review. An investigation of phosphate loss from phosphopeptide ions was conducted, using both atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) and electrospray ionization (ESI) coupled to an ion trap mass spectrometer (ITMS).

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Missense and nonsense mutations in the alternatively-spliced exon 2 of COL2A1 cause the ocular variant of Stickler syndrome. This study describes the clinicopathological features of three cases. The evolution of the dominating defect properties is studied through noise spectroscopy. Patients receiving unexpected diagnoses had more psychological symptoms than patients receiving expected diagnoses.

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Two hundred and fifty-one women randomised to aromatherapy and 262 controls. Stereospecific synthesis of (2S,3R)-2-amino-3-mercaptobutyric acid--an intermediate for incorporation into beta-methyllanthionine-containing peptides.

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Zfp488 is a nuclear protein that possesses transcriptional repression activity. Osmoregulation and Na,K-ATPase expression in osmoregulatory organs of Scylla paramamosain. The infectivity and host range of ground squirrel hepatitis virus (GSHV) have been further examined by animal inoculation experiments. The ectopic expression of SOX17 in both embryonic and adult blood cells enhances self-renewal.

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Furthermore, glucocorticoid-induced transcriptional activation of GR was enhanced in cells treated with a calpain inhibitor. Using Digital Imaging and Communication in Medicine data obtained from preoperative cerebral angiography, a vessel model was produced with a 3D printer using acrylic resin. Because cofilin has been implicated previously in the structural plasticity of spines, this signaling may enable cofilin to depolymerize actin filaments and restructure spines at sites of ephrin-EphA4 contact.

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A case is presented of a 72-year-old female, with a history of renal carcinoma in the right kidney treated by total nephrectomy. While the exact etiology of these findings is not clear, the timing of surgical procedures should be considered in the context of systems-based deficiencies that may be detrimental to pediatric surgical care. Various types of aglomerular shunts were observed regardless of the cystic stage or age. Dietary intakes were assessed using a 7 d weighted dietary record method, coupled with the collection of duplicate diets.

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Here we consider the role of few selected regulatory proteins that are most frequently involved in the processes of activation, cell differentiation and proliferation of human hematological malignant cells. In this article, we identify a NifEN-bound FeMoco precursor form that can be converted to fully assembled FeMoco in a so-called FeMoco-maturation assay containing only purified components. New telomere formation during the process of chromatin diminution in Ascaris suum.

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Parametric and resonant transition radiation in periodic stratified structures. Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. Elevated concentrations of the endogenous NO synthase antagonist asymmetrical dimethylarginine (ADMA) may be related to the development of atherosclerosis and are associated with cardiovascular risk. After dentin protein was extracted, the concentrations of MMP-2 in different tooth were detected using fluorescent microsphere immunoassay.

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Leukotrienes (LTs) are involved in airway eosinophilic inflammation in patients with asthma. The susceptibility of Xenopus (Silurana) tropicalis and Rana temporaria to ethynylestradiol (EE2), a potent estrogenic pharmaceutical and environmental pollutant, was investigated. We report measurements of the fluidization process in vertically vibrated two-dimensional granular packings.

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Bridges linking gap junction particles extracellularly: a freeze-etching rotary-shadowing study of split junctions. The structure of terpestacin was elucidated as a bicyclic sesterterpene on the basis of spectroscopic data and chemical derivatization. Clinical and functional study of four cases of liver cirrhosis treated by ligation of the hepatic artery alone and with ligation of splenic artery and splenectomy Strong evidence for homology was found for COL4A1, COL4A2, D13S26, D13S35, and F10, but only circumstantial homology evidence was obtained for PCCA. The existence of such regulatory mechanisms in skeletal muscle has long been hypothesized but has never been demonstrated.

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Real-time probe based quantitative determination of material properties at the nanoscale. Traumatic sternal segment dislocation in a 3-year-old girl: Sonographic findings.

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A section on the quantification of the complexity of classification problems is included. Cholesteryl ester transfer protein TaqIB polymorphism and its relation to parameters of the insulin resistance syndrome in an Austrian cohort. One of the investigators administered a questionnaire to clinicians who perform procedures on children at an academic tertiary care pediatric hospital to assess knowledge of assent for medical treatment and familiarity with the American Academy of Pediatrics policy statement on assent and to measure clinician attitudes and approaches to consent/assent in pediatrics.

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Cancer is one of the most life-threatening diseases with many forms still regarded as incurable. In the secondary forest, tamarins did not capture flushed prey, which make up a substantial part of the total prey captures biomass in primary forests. Genome- and proteome-based technologies: status and applications in the postgenomic era.

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Patients were subdivided into 2 groups: 37 simultaneously treated on the thyroid and the neck (Group A), and 15 operated elsewhere on the thyroid and for a neck recurrence and/or persistence at our Department (Group B). To describe oral health-related quality of life (OHRQoL) among New Zealand adults and assess the relationship between clinical measures of oral health status and a well-established OHRQoL measure, controlling for sex, socioeconomic status (SES) and use of dental services. In this paper requirements for meaningful empirical estimates of the willingness to accept lower per capita health status in order to achieve greater equity are examined. Particle release positions were assigned employing a random number generator following random-parabolic, random-uniform, and random-random distribution functions.

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Our results indicate that elastography is a novel method that can be readily used to characterize the mechanical properties of the ACL and its insertions into bone. The number of lymph node metastases and the amount of body weight loss significantly decreased by intraperitoneal administration of R-94138. Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. Both fixations gave good preservation of ultrastructural details and data from the two sample types were highly complementary.

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The role of daily physical activity and nutritional status on bone turnover in cystic fibrosis: a cross-sectional study. qiRNApredictor: A Novel Computational Program for the Prediction of qiRNAs in Neurospora crassa. After 3 and 5 days of 0.2 mg/h NTG i.v., the dose-response relations for NTG-induced reduction in blood pressure were shifted to 25-fold higher doses (P less than .01). The minipig was not an appropriate biomodel for the study of alveolar distraction because the investigators were not able to maintain the seal of the distraction chamber or the stability of the distractor.

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Categorical and metric distance information in mental representations derived from route and survey descriptions. After the completion of the genomic sequencing of model organisms, numerous post-genomic studies, integrating transcriptome and metabolome data, are aimed at developing a more complete understanding of cell physiology.

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Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation. Multivariate logistic regression was performed using clinical elements available in the database to identify independent predictors of GCSE.

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The two most common activating mutations of the Flt3 gene, ie, internal tandem duplication and D835 point mutation, were assessed by specific polymerase chain reaction. At the same time, the identification of unexpected morphogenetic processes occurring during mouse gastrulation has challenged established dogmas and brought new insights into the mechanisms driving germ layer formation.

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An androgenic affinity ligand covalently binds to cytosolic aldehyde dehydrogenase from human genital skin fibroblasts. The drug conjugate was nearly 100 times as effective as free PAS in killing the intracellular mycobacteria in mouse peritoneal macrophages infected in culture with Mycobacterium tuberculosis. Statements on emerging surgical technologies and the evaluation of credentials. Imaging and pathology showed atrophy and degeneration of the basal ganglia.

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In chickens, a decrease was observed in every brain area after 36 h of starvation. Yeast and mammalian cells use a variety of different mechanisms to ensure that the endoplasmic reticulum and Golgi apparatus are inherited by both daughter cells on cell division. This work also suggests that improving photosynthetic efficiency under field conditions will require the consideration of multiple factors, such as stress responses. Similar results were obtained with B-cell hybridomas derived from mild insulinic lesions of diabetes-resistant (NOD x NOR)F1 and 8.3-(NOD x NOR)F1 mice.

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